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Nov 7 14 9:36 AM

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Acute Flaccid Myelitis is polioencephalomalacia



In August 2012, the California Department of Public Health (CDPH) was contacted by a San Francisco Bay area clinician who requested poliovirus testing for an unvaccinated man aged 29 years with acute flaccid paralysis (AFP) associated with anterior myelitis (i.e., evidence of inflammation of the spinal cord involving the grey matter including anterior horn cell bodies) and no history of international travel during the month before symptom onset. Within 2 weeks, CDPH had received reports of two additional cases of AFP with anterior myelitis of unknown etiology. Testing at CDPH's Viral and Rickettsial Disease Laboratory for stool, nasopharyngeal swab, and cerebrospinal fluid (CSF) did not detect the presence of an enterovirus (EV), the genus of the family Picornaviridae that includes poliovirus. Additional laboratory testing for infectious diseases conducted at the CDPH Viral and Rickettsial Disease Laboratory did not identify a causative agent to explain the observed clinical syndrome reported among the patients. To identify other cases of AFP with anterior myelitis and elucidate possible common etiologies, CDPH posted alerts in official communications for California local health departments during December 2012, July 2013, and February 2014. Reports of cases of neurologic illness received by CDPH were investigated throughout this period, and clinicians were encouraged to submit clinical samples for testing. A total of 23 cases of AFP with anterior myelitis of unknown etiology were identified. Epidemiologic and laboratory investigation did not identify poliovirus infection as a possible cause for the observed cases. No common etiology was identified to explain the reported cases, although EV-D68 was identified in upper respiratory tract specimens of two patients. EV infection, including poliovirus infection, should be considered in the differential diagnosis in cases of AFP with anterior myelitis and testing performed per CDC guidelines (1).


http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6340a6.htm?s_cid=mm6340a6_w


  
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#3 [url]

Nov 10 14 8:14 AM

Girl paralyzed after complications with Enterovirus D68

CINCINNATI, Ohio (WDTN) – A Piqua girl is continuing to battle complications that stem from catching Enterovirus D68.
Madison Grigsby, 8, was like any other happy and healthy child up until September 22. That is the day her mother said changed her life forever.
“She was home when she collapsed,” said Erin Carey, Madison’s mother. “She was actually getting ready to get in the shower.”
http://wdtn.com/2014/10/27/girl-paralyzed-after-complications-with-enterovirus-d68/

FYI: Acute Flaccid Myelitis is polioencephalomalacia

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#4 [url]

Nov 10 14 9:08 AM

On Sunday, November 16th, the Peacock Inn in Princeton will celebrate the brief life of one of the youngest members of its extended family: four-year-old Eli Waller, who in September went to bed seemingly healthy and died in his sleep from enterovirus D68.
On September 24th, Eli's parents, Suzie and Andy Waller, who live in Hamilton Township, kept Eli home from preschool with a mild case of pink eye. He went to sleep that night apparently healthy, but succumbed during the night the night to what tests later determined was enterovirus D68, a potent respiratory virus most active in summer and fall in this part of the country.
http://njmonthly.com/blogs/soup-to-nuts/2014/11/10/remembering-eli-waller-4-felled-by-enterovirus-d68.html

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#5 [url]

Nov 13 14 6:48 AM

Acute Flaccid Myelitis is polioencephalomalacia ( PEM )

CDC releases guidance on acute flaccid myelitis

New interim guidance from the Centers for Disease Control and Prevention (CDC) suggest that no targeted therapies or interventions have “definitive efficacy” in the treatment or management of acute flaccid myelitis.

Interim Considerations for Clinical Management of Patients with Acute Flaccid Myelitis,” issued Nov. 7, is based on consensus guidance drawn from experts in infectious diseases, neurology, pediatrics, critical care medicine, public health epidemiology and virology. The CDC has fielded numerous requests on how to manage and treat children with this illness.

The most important issue summarized in the document is that there is no clear evidence that therapies intended to modify the immune system (e.g., corticosteroids, immune globulin, plasmapheresis) have a beneficial effect in this condition,”

http://aapnews.aappublications.org/content/early/2014/11/12/aapnews.20141112-1

Also see: http://www.cdc.gov/ncird/investigation/viral/sep2014.html

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#6 [url]

Nov 14 14 3:25 PM


USA TODAY 4:21 p.m. EST November 14, 2014

Unexplained, polio-like illness has paralyzed 75 kids

An unexplained, polio-like illness has now affected 75 children across the country, according to the Centers for Disease Control and Prevention.

The first cases were reported in August in Colorado, around the same time that children began going to the emergency room with breathing problems related to enterovirus D68, according to the CDC. The CDC reports 1,116 cases of the enterovirus in 47 states and Washington, D.C. recent months, almost all in children. Twelve children with the virus have died.



http://www.usatoday.com/story/news/nation/2014/11/14/enterovirus-deaths-paralysis/19040405/

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#8 [url]

Nov 19 14 11:34 AM

Nov 17, 2014



Michigan: enterovirus d68 proves to be an issue in the state

This year, the Washtenaw County Department of Public Health reported two positive cases in the county. One patient is an adult with a history of asthma and the other is seven-month-old infant. The season for EV-D68 typically ends with the onset of winter.

Though Lozon and her colleagues do not know if EV-D68 causes flaccid paralysis — a symptom that characterizes polio, another enterovirus-related disease — her department saw a cluster of seven patients of various ages and from different parts of Michigan admitted with flaccid paralysis of lower and upper extremities in a period of a week and a half.

http://www.michigandaily.com/news/entreovirus-season-ending

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#10 [url]

Mar 20 15 4:03 PM

OLD NEWS! But interesting!
These were the first two reports I read on AFP which lead me to believe AFP and PEM were connected. Please note the date.

Feb. 14, 2014 California Firm Recalls Unwholesome Meat Products Produced Without the Benefit of Full Inspection
“WASHINGTON, Feb. 14, 2014 – Rancho Feeding Corporation, a Petaluma, Calif. establishment, is recalling approximately 8,742,700 pounds, because it processed diseased and unsound animals and carried out these activities without the benefit or full benefit of federal inspection. Thus, the products are adulterated, because they are unsound, unwholesome or otherwise are unfit for human food and must be removed from commerce, the U.S. Department of Agriculture’s Food Safety and Inspection Service (FSIS) announced today.
http://www.fsis.usda.gov/wps/portal/fsis/topics/recalls-and-public-health-alerts/recall-case-archive/archive/2014/recall-013-2014-release

SUNDAY, Feb. 23, 2014 (HealthDay News) -- A rare "polio-like syndrome" has caused paralysis in about 20 children from across California, according to a report released Sunday by physicians in the San Francisco Bay Area.

http://consumer.healthday.com/public-health-information-30/centers-for-disease-control-news-120/mysterious-polio-like-illness-is-striking-kids-in-california-685110.html

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#11 [url]

Apr 27 15 4:23 PM

Community Comes Together To Raise Money For Teen Battling Rare Illness


“ mysterious illness --In December, Fisher was diagnosed with acute flaccid myelitis-a rare polio-like disease ----According to the Centers for Disease Control and Prevention, reports were verified of 118 children in 34 states affected with the illness from Aug. 2, 2014 to April 14, 2015.”

http://www.keyt.com/news/community-comes-together-to-raise-money-for-teen-battling-rare-illness/32583622

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